![]() Other screening methods also have some defects related to screening effectiveness, sensitivity and specificity. However, the limitations such as uncomfortable experience, expensive cost and complications restrict its widespread application. So far, coloscopy is regarded as the gold standard for the diagnosis of CRC. Therefore, a majority of patients are diagnosed in the advanced stage, and lost the opportunity to receive the most appropriate treatment. When present, symptoms often develop insidiously over a period of months and years. CRC can remain clinically silent for years. Meanwhile, the combined detection of tumor markers with MPV/PC can improve the diagnostic value of CRC, revealing the potential of MPV/PC as a promising screening tool in CRC early diagnosis.Ĭolorectal cancer (CRC) is the most common gastrointestinal malignant tumor with enormous disease and economic burden, ranking third in incidence and second in mortality rate. Preoperative MPV/PC in peripheral blood of patients with CRC was lower than the control group. MPV/PC was associated with tumor infiltration, regional lymph node metastasis, differentiation and nerve invasion (P < 0.05) and the combination of MPV/PC with the three tumor markers produced a larger AUC with higher sensitivity, specificity and Yuden index than MPV/PC or the three tumor markers used alone to distinguish between CRC and colorectal polyps. For subgroups regarding tumor anatomical location, both CA125 and CA199 were higher in colon cancer group than rectum cancer group (P = 0.0322, P = 0.0094). ![]() Among the three tumor markers, higher CA125 was correlated with distant metastasis and lower differentiation (P < 0.05), increased CA72-4 indicated positive nerve invasion (P = 0.0174), and elevated CA199 was associated with lymphatic metastasis and positive vascular invasion (P < 0.05). The MPV/PC in CRC group was significantly lower than the control group (P < 0.0001). Hematological and pathological parameters of the above patients were collected, data were analyzed with Student’s t-test, one-way ANOVA or Kruskal-Wallis H test and receiver operating characteristic (ROC) curve, and ROC curve was used to evaluate the diagnostic value of tumor markers and MPV/PC used alone or in combination in CRC. MethodsĢ00 patients with CRC and 317 patients with colorectal benign polypus pathologically diagnosed during 4 to 0 were included. This retrospective clinical study aimed to evaluate the diagnostic value of MPV/PC and tumor markers (CA72-4, CA125, CA199) used alone or in combination in CRC. However, only a few studies investigated the value of MPV/PC in colorectal cancer (CRC) and the combination of MPV/PC with tumor markers in CRC. The ratio of MPV to PC (MPV/PC) has an essential role in the diagnosis of multiple malignancies. Mean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC).
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